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Delayed antibiotic prescribing is a safe and effective for respiratory tract...
1. There was no difference in follow-up symptom severity between patients who received immediate or delayed antibiotics for respiratory tract infections. 2. Delaying antibiotics was associated with...
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Anti-psychotic medication use during pregnancy not associated with...
1. Children of mothers who were exposed to anti-psychotics during pregnancy, compared to those never exposed, did not have an increased risk of autism spectrum disorders (ASDs),...
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Betibeglogene autotemcel gene therapy effective for β-thalassemia
1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0 genotype patients. 2. The gene therapy resulted in a...
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LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling hemoglobin, HbAT87Q. 2. LentiGlobin led to reduced hemolysis and resolved severe vaso-occlusion from sickle...
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Valoctocogene roxaparvovec gene therapy efficacious for hemophilia A treatment
1. The adeno-associated virus 5 (AAV5)-based gene therapy, valoctocogene roxaparvovec (AAV5-hFVIII-SQ), resulted in sustained factor VIII production, reduced bleeding rates, and need for factor VIII...
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Iberdomide elicits SRI-4 response in patients with systemic lupus erythematosus
1. More patients with systemic lupus erythematosus (SLE) who received high doses of iberdomide achieved SRI-4 response compared to placebo and other doses. Evidence Rating Level: 1 (Excellent)...
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Familial natural short sleep mutations may reduce Alzheimer’s Disease...
1. Certain sleep phenotypes, such as those with the familial natural short sleepers (FNSS) mutation, anecdotally do not exhibit the neurocognitive changes of Alzheimer’s Disease. 2. In this study, the...
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Ziltivekimab associated with multiple proatherogenic inflammatory pathways –...
1. In this secondary analysis of the RESCUE trial, targeted interleukin 6 (IL-6) ligand inhibition with ziltivekimab was associated with a lower neutrophil-lymphocyte ratio (NLR) at week 12, suggesting...
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No known association between PCSK9 gene variants and risk of heart failure
1. There was no association detected between PCSK9 gene variants and alterations in cardiac morphology. 2. The odds of having heart failure were not significantly different in individuals with PCSK9...
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The emergence of visual artistic creativity in frontotemporal dementia: a...
1. This case-control study of 689 patients with frontotemporal dementia demonstrated that visual artistic creativity emerged in 17 patients (2.5%), often manifested early in the disease, and was...
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